Once again, the eye can reveal the body’s secrets. In a recent analysis, Retinal pathological features and proteome signatures of Alzheimer’s disease, published in Acta Neuropathologica, Cedars-Sinai investigators looked at post mortem retinal and brain tissue samples collected over 14 years from 86 human donors and compared samples from donors with normal cognitive function to those with mild cognitive impairment at the earliest stages of Alzheimer’s disease, as well as those with later-stage dementia. (Koronyo, Y., Rentsendorj, A., Mirzaei, N. et al. Retinal pathological features and proteome signatures of Alzheimer’s disease. Acta Neuropathol (2023). https://doi.org/10.1007/s00401-023-02548-2)