Volume 9, Number 19
Monday, May 18, 2009



In this issue: (click heading to view article)
Association Between Dietary Fatty Acids and AMD
Effect of Postop Lens Status on IOP in Proliferative Vitreoretinopathy
Myopia Progression with Corneal Reshaping Lenses
RNFL and Cognitive Functioning
Briefly





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Association Between Dietary Fatty Acids and AMD

The researchers for the Blue Mountains Eye Study sought to assess the relationship between baseline dietary fatty acids and 10-year incident age-related macular degeneration (AMD). In an elderly Australian cohort, they examined 3,654 participants at baseline and 2,454 5 and/or 10 years later. The researchers assessed AMD from retinal photographs and participants completed a semi-quantitative food frequency questionnaire.

After adjusting for age, sex and smoking, the researchers associated one serving of fish per week with reduced risk of incident early AMD (relative risk, 0.69 [95% confidence interval, 0.49-0.98]), primarily among participants with less than the median linoleic acid consumption (0.57 [0.36-0.89]. Findings were similar for intake of long-chain -3 polyunsaturated fatty acids. One to two servings of nuts per week was associated with reduced risk of incident early AMD (relative risk, 0.65 [95% CI, 0.47-0.91]) and protective associations between the intake of nuts and reduced risk of pigmentary abnormalities were seen among nonsmokers, participants with less than the median ratio of serum total to high-density lipoprotein cholesterol and those with beta carotene intake greater than the median level.

According to the researchers, this study provides evidence of protection against early AMD from regularly eating fish, greater consumption of -3 polyunsaturated fatty acids and low intakes of foods rich in linoleic acid. Regular consumption of nuts may also reduce AMD risk.

SOURCE: Tan JSL, Wang JJ, Flood V, Mitchell P. Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. Arch Ophthalmol 2009;127(5):656-665.






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Effect of Postop Lens Status on IOP in Proliferative Vitreoretinopathy

The aim of this retrospective, consecutive, nonrandomized, single-center series was to determine the influence of lens status on postoperative IOP in eyes undergoing vitrectomy for repair of recurrent retinal detachment (RD) resulting from proliferative vitreoretinopathy (PVR).

A total of 145 eyes with recurrent RD resulting from PVR were reviewed retrospectively and 99 of these eyes (68.4%) underwent relaxing retinotomy at the time of surgery. Perfluorocarbon gas (n=60) or silicone oil (n=85) were used as postop tamponades and for analysis, eyes were subdivided first based on tamponade and retinotomy status. The resultant groups were subsequently divided further by lens status into two groups: aphakic eyes (aphakic group) and phakic and pseudophakic eyes (nonaphakic group).

Surgical reattachment was achieved in all eyes except one. Moreover, eyes receiving both silicone oil and relaxing retinotomy had the worst baseline characteristics compared with those receiving other interventions. In this subset of eyes, a significantly lower proportion of hypotony was found in those that were aphakic after surgery when compared with those eyes that were nonaphakic (p=.037).

It was determined that removal of the lens or IOL implant may be considered for those eyes at greatest risk of hypotony.


SOURCE: Tseng JJ, Schiff WM, Barile GR, et al. Influence of postoperative lens status on intraocular pressure in proliferative vitreoretinopathy. Am J Ophthalmol 2009;147(5):875-885.






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Myopia Progression with Corneal Reshaping Lenses

Investigators fit 40 subjects (aged 8-11 years with between -0.75D and -4.00D myopia and <1.00D astigmatism) with corneal reshaping contact lenses to determine whether corneal reshaping lenses slow eye growth, as anectodal evidence indicates. They age-matched subjects to a soft contact lens wearer from another myopia control study and performed A-scan ultrasound at baseline as well as annually for two years.

According to the study investigators, 28 (70%) subjects wore corneal reshaping contact lenses for two years. While the refractive error and axial length were similar between the two groups at baseline, the corneal reshaping group had an annual rate of change in axial lengths that was significantly less than the soft contact lens wearers (mean difference in annual change = 0.16 mm, p=0.0004). Additionally, vitreous chamber depth experience similar changes (mean difference in annual change = 0.10 mm, p=0.006).

The results of their study confirm previous reports of slowed eye growth following corneal reshaping contact lens wear.

SOURCE: Walline JJ, Jones LA, Sinnott LT. Corneal reshaping and myopia progression. Br J Ophthalmol 2009; May 4 [Epub ahead of print].







RNFL and Cognitive Functioning

The authors of this study assessed the association between cognitive functioning and retinal nerve fiber layer (RNFL) thickness in a large, population-based sample. Their findings led them to conclude that cognitive functioning is associated with RNFL thickness in healthy, young individuals.

They performed neuropsychological and ophthalmic examinations in 1,485 healthy individuals (mean age, 46 years; range 18-85) from a study in a genetic isolate from the Netherlands (the Erasmus Rucphen Family [ERF] study) and assessed different domains of cognitive functioning with the Dutch Adult Reaading Test, the Rey Auditory Verbal Memory Test, semantic fluency, the Trail Making Test, the Stroop color-word test and Block Design. Furthermore, the authors measured RNFL thickness with scanning laser polarimetry and studied the association between cognitive test scores and peripapillary RNFL thickness with linear regression analyses, adjusting for age, gender, level of inbreeding and refractive error.

After adjusting for confounders, a better cognitive performance was statistically significantly associated with a thicker RNFL in all tests (p<0.03) except for the Stroop color-word test (p-0.15). The authors submit that RNFL thickness explained up to 2.8% (R2=0.028) of the total variance in cognitive test scores. The association diminished in age groups beyond 40 years, but they contend that this lack of association in older individuals suggests that loss of neurons in the cerebrum and retina is not concomitant and may have different origins.

SOURCE: van Koolwijk LME, Despriet DDG, van Duijn CM, et al. Cognitive functioning is related to retinal nerve fiber layer thickness. Invest Ophthalmol Vis Sci 2009; May 6 [Epub ahead of print].

 




  • B&L RECEIVES NTIOL DESIGNATION FOR ASPHERIC IOL, ANNOUNCES EXECUTIVE CHANGES. The Centers for Medicare and Medicaid Services (CMS) granted a New Technology Intraocular Lens (NTIOL) designation to Bausch & Lomb's Akreos Advanced Optics Aspheric (Akreos AO) IOL for its spherical aberration reducing design. (NTIOL designation means the Medicare reimbursement to ambulatory surgery centers for cataract surgery will increase by $50 when surgery is performed with the Akreos AO IOL. And will remain in effect until February 26, 2011.) In order to gain inclusion in the NTIOL category, the Akreos AO lens demonstrated the same or greater subset-specific clinical benefit as the lens that established the NTIOL subset.

    In other company news, Peter Valenti III has been named as corporate vice president and global president, Vision Care, effective July 1. He replaces Stuart Heap, who has chosen to step down from his current role with Bausch & Lomb for personal reasons effective June 30. Mr. Heap will remain an active strategic advisor to the company. In conjunction with Mr. Valenti's transition to his new role, the company has named Steven F. Robins as president, North America, Vision Care.
  • NANOVIRICIDES SIGNS STUDY AGREEMENT FOR HERPES KERATITIS DRUG. In a recent press release, NanoViricides, Inc. announced that it has signed a pre-clinical study agreement for the evaluation of its drug candidate for herpes keratitis of the eye. According to NonViricides, the study will be conducted by Thevac, LLC, a spinoff of the Louisiana State University (LSU), Baton Rouge, LA, and will be performed in collaboration with the Division of Biotechnology and Molecular Medicine at the LSU School of Veterinary Medicine. Visit the company's web site to learn more.
  • ALCON ANNOUNCES WAVELIGHT PLANS. Alcon, Inc. has achieved ownership of more than 95 percent of the share capital of WaveLight AG. Under the provisions of the German Stock Corporation Act, Alcon is deemed to be the principal shareholder of WaveLight's approximately 6.6 million issued and outstanding shares. The company has notified the WaveLight board of directors of its intention to acquire all remaining outstanding shares in accordance with the “squeeze-out” provisions of German securities law. Read more here.
  • NEW RESEARCH INSTITUTE TO OPEN IN FLORIDA. The Tampa Lions Eye Institute for Transplant and Research, Inc. plans to open a new 12,000-square-foot facility to offer high-volume, high-quality human ocular tissue for research, study, collaboration and clinical advancements. The state-of-the-art facility will boast extensive space for on-site residence, sleeping quarters and meetings/events. For more information, visit www.lionseyeinstitute.org.